Macrophages require Skap2 and Sirpa for integrin-stimulated cytoskeletal rearrangement
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چکیده
Francis J. Alenghat, Quentin J. Baca, Nooreen T. Rubin, Lily I. Pao*, Takashi Matozaki, Clifford A. Lowell, David E. Golan, Benjamin G. Neel and Kenneth D. Swanson Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA Cardiovascular Division, Brigham and Women’s Hospital, Boston, MA 02115, USA Division of Signal Transduction, Departments of Medicine and Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA Hematology Division, Brigham and Women’s Hospital, Boston, MA 02115, USA
منابع مشابه
Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.
Macrophages migrate to sites of insult during normal inflammatory responses. Integrins guide such migration, but the transmission of signals from integrins into the requisite cytoskeletal changes is poorly understood. We have discovered that the hematopoietic adaptor protein Skap2 is necessary for macrophage migration, chemotaxis, global actin reorganization and local actin reorganization upon ...
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Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The Src kinase-associated phosphoprotein 2 (Skap2) is involved in integrin functions in different leukocyte subtypes. However, the role of Skap2 i...
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Macrophages require activation with either PMA (Mercurio, A. M., and L. M. Shaw. 1988. J. Cell Biol. 107:1873-1880) or interferon-gamma (Shaw, L. M., and A. M. Mercurio. 1989. J. Exp. Med. 169:303-308) to adhere to a laminin substratum. In the present study, we identified an integrin laminin receptor on macrophages and characterized cellular changes that occur in response to PMA activation that...
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تاریخ انتشار 2013